David J. Mooney
- Robert P. Pinkas Family Professor of Bioengineering
- Core Faculty Member, Wyss Institute for Biologically Inspired Engineering at Harvard University
The basic question that drives Mooney's research is: how do mammalian cells receive information from the materials in their environment.
By utilizing the tools of cell and molecular biology, he studies the mechanisms by which chemical (for example, specific cell adhesion molecules) or mechanical signals (for example, cyclic strain) are sensed by cells and alter their proliferation and specialization to either promote tissue growth or destruction.
Mooney uses the results from these studies to design and synthesize new biomaterials that regulate the gene expression of interacting cells for a variety of tissue engineering and drug delivery projects. Current projects focus on therapeutic angiogenesis, regeneration of musculoskeletal tissues, and cancer therapies.