Neuromuscular junctions - Hannah Storrie
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1. Neuromuscular junctions - Hannah Storrie; 2. Fluorescent endothelial sprouting assay - Eduardo Silva; 3. SEM microscopy - Claudia Fischbach; 4. Endothelial sprouting assay - Will Yuen; 5. Histology - Eduardo Silva; 6. Histology - Eduardo Silva; 7. Cells adhering to a surface - James Cunningham; 8. SEM microscopy - Claudia Fischbach;

Praveen R Arany
Graduate student-Resident
arany@fas.harvard.edu

Education

2006 - Present: I am pursuing a program in three fields namely; Graduate program in Biological Sciences in Dental Medicine, GSAS-HSDM; Certificates in Translational Human Research in Leder Medical Sciences Program, HHMI-HMS and Residency in Oral and Maxillofacial Pathology, HSDM-Brigham and Women's Hospital, Boston.

2004-2006: Certificate in Clinical Research Curriculum - NIH, Bethesda MD

2003-2006: Postdoctoral Fellow, National Cancer Institute, NIH, Bethesda, MD

2001-2003: Postdoctoral Fellow, Indian Institute of Science, Bangalore, India

1999-2001: Masters in Dental Surgery (MDS) KLE's Institute of Dental Sciences, Belgaum, India

1994-1999: Bachelors in Dental Surgery (BDS) KLE's Institute of Dental Sciences, Belgaum, India

"Awards"
Harvard Presidential Scholarship, Harvard School of Dental Medicine Sep 2007.

Chairman’s Travel award, Gordon Research Conference ‘Wound Healing and Regeneration', New Hampshire, June 2007.

Young Investigator Award, Society of Advanced Wound Care and Wound Healing Society (SAWC-WHS), Tampa, Florida May 2007.

NIH Merit Award, Center for Cancer Research Fellows and Young Investigators (CCR-FYI), Bethesda, MD USA Oct 2006.

NCI Director’s Innovation Award, National Cancer Institute, NIH, Bethesda, MD USA Jan 2006

Awarded Best Paper and Poster at National Conference of the Indian Academy of Oral And Maxillofacial Pathologists, Pondicherry, India 1999 and 2001.

Awarded Best Poster and Paper at Scientific Convention, K.L.E.S’s Institute of Dental Sciences, Belgaum, India 1999.

Research Focus

I am a biologist interested in understanding the molecular basis of Wound Healing & Regeneration, Cellular Differentiation and Malignant Tranformation. My main focus in the Mooney lab is to analyze the interface of cells and their matrix. The experimental systems I use in the lab address the intricate signaling pathways involved in normal cues (Development) and how these become aberrant during pathology (Cancers) using a reverse-engineering approach to design in vitro systems that attempt to simulate the in vivo milieu. I use a combination of cell-molecular biology tools and mice models to analyse these pathways while I am also presently learning to use material science and bioengineering techniques in my projects. With my background and present training progams, I hope to 'translate' our findings to a clinical setting for practical use in diagnosis, prognosis and therapeutics.

Publications

  • Arany PR, Flanders KC, Kobayashi T, Kuo CK, Stuelten CH, Desai K, Tuan R, Rennard SI and Roberts AB. Smad3 deficiency alters key structural elements of the extracellular matrix and the mechanotransduction of wound closure. Proceedings of National Academy of Sciences 2006, June 13; 103; 24; 9250-9255.
  • Arany PR, Flanders KC, DeGraff W, Cook J, Mitchell JB and Roberts AB. Absence of Smad3 confers radioprotection through modulation of ERK MAPK in primary dermal fibroblasts. Journal of Dermatological Science 2007, Oct 48 (1), 35-42.
  • Arany PR, Nayak RS, Hallikerimath S, Limaye AM, Kale AD and Kondaiah P. Activation of Latent TGF-beta1 by low power laser in vitro correlates with increased TGF-beta1 levels in laser enhanced oral wound healing. Wound Repair and Regeneration 2007, 15 (6), 866-874.
  • Arany PR, Rane S and Roberts AB. Smad3 deficiency inhibits v-Ras induced transformation by suppression of JNK MAPK and increased farnesyl transferase inhibition. Oncogene Advanced online 2007 Oct 22.
  • Arany PR ‘Introduction to Laboratory Analyses in Oral and Maxillofacial Pathology’ appendix in Schafer’s Textbook of Oral and Maxillofacial Pathology, 5th Edition Editors: R Rajendran and B Sivapathasundharam, Elsevier, India.
  • Arany PR ‘Photobiomodulation by low power laser irradiation involves activation of latent TGF-beta1’ chapter in Light Activated Tissue Regeneration and Therapy, Editors: Ron Waynant and Darrell Tata, Springer USA (in press).
  • Stuelten CH, Byfield SD, Arany PR, Karpova TS, Stetler-Stevenson WG, Roberts AB. Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-beta. Journal of Cell Sciences 2005 May 15; 118; 10; 2143-53.
  • Hudson TS, Hartle D, Hurstings S, Nunez N, Perkin S, Young S, Arany PR, Green JE. Inhibition of Prostate Cancer Growth By Resveratrol And Muscadine Grape Skin Extract Through Distinct Mechanisms. Cancer Research 2007, 67 (17), 8396.