Postdoctoral Fellow
borselli@deas.harvard.edu
Education
“Laurea” degree in Biological Science (1999) –Federico II University of Naples, Italy.Ph.D. in Biomaterials (2004) – Department of Materials and Production Engineering,
Engineering School, Federico II University of Naples, Italy.
Postdoctoral Research Fellow (2004-2006) – Department of Materials and Production Engineering
Engineering School, Federico II University of Naples, Italy.
Postdoctoral Research Fellow (fall 2006-present) –Department of Engineering and Applied Sciences (DEAS), Harvard University, Cambridge, USA.
Research Focus
In remodeling tissues, the formation of new blood vessels (angiogenesis) is a fundamental process and is an essential component of virtually all tissue-engineering strategies. The principal constraint of current efforts in regenerative tissue is to recreate the special micro-environmental gradients of regulatory factors that are critical to mimic nature’s program of vascular morphogenesis. In previous study, I have created gradient of matricellular cues and I have demonstrated the importance that spatial gradient distribution of ECM insoluble factors have in inducing directional sprouting angiogenesis processes. To improve the angiogenic capability of engineered tissues, my ultimate goal is to design biodegradable polymer vehicles able to provide a spatio-temporal controlled delivery of cells and/or regulatory factors in both in vitro and in vivo models. My past research projects included engineering cartilage and design of biomaterials utilized for protein delivery.Publications
- Pisanti S., Borselli C., Oliviero O., Laezza C., Gazzerro P., Bifulco M. Angiogenic activity of the endocannabinoid anandamide. International Journal of Cancer (in press)
- Borselli, C., Oliviero O., Battista S., Ambrosio L., Netti P.A. Induction of directional sprouting angiogenesis by matrix gradients. J Biomed Mater Res A. 2006 Sep 7.
- E De Rosa, F Urciuolo, C Borselli, D Gerbasio, G Imparato, P A Netti. Time and space evolution of transport properties in agarose-chondrocyte constructs. Tissue Eng. 2006 Jul 1.
- E De Rosa, C Borselli, P. A. Netti. Transport of large molecules in hyaluronic acid -based membranes and solution.” Journal of Membrane Science 273 (2006) 84-88.
- Battista, S., Guarnieri, D., Borselli, C., Zeppetelli, S., Borzacchiello, A., Mayol, L., Gerbasio, D., Ambrosio, L. and Netti, P.A. The effect of matrix composition of 3D constructs on embryonic stem cell differentiation. Biomaterials. 2005 Nov;26(31):6194-207.
- Borselli, C., Guarnieri, D., Battista, S., Oliviero, O., Netti, P. e Ambrosio, L. (2005) Ruolo dell'interazione cellula-materiale sul controllo di funzioni cellulari in "Biomateriali: dagli impianti protesici alla medicina rigenerativa". Pŕtron Editore. pp. 121-137.
- Ambrosio L, Battista S, Borzacchiello A, Borselli C, Causa F, De Santis R, Netti PA, Zeppetelli S. Biomimetic structures for implants and tissue engineering scaffolds. Med J Malaysia. 2004 May; 59 Suppl B:71-2.
- G. Portella, C. Borselli, M. Santoro, D. Gerbasio, M.R. D’Armiento, J.E. Dumont, C. Ledent, J.L. Rothstein, G. Vecchio and A. Fusco. Human Papilloma Virus 16-E7 Oncogene does not cooperate with RET/PTC3 Oncogene in the neoplastic trasformation of thyroid cells in transgenic mice. Oncology Research, Vol. 12, pp.1-8; 2000.
- G. Portella, D.Vitagliano, C. Borselli, R.M. Melillo, D. Salvatore, J.L. Rothstein, G. Vecchio, A. Fusco and M. Santoro. Human N-ras,TRK-T1 and RET/PTC3 oncogenes, driven by a thyroglobulin promoter, differently affect the expression of differentiation markers and proliferation of thyroid epithelial cells. Oncology Research, Vol. 11, pp 1-7; 1999.