Eduardo A. Silva
Postdoctoral Fellow
easilva@seas.harvard.edu
Education
Ph.D. ( University of Porto, Portugal & Harvard University & University of Michigan) 2002-2008Gulbenkian PhD Programme in Biomedicine (Gulbenkian Science Institute, Portugal) 2001-2005
Metallurgical and Materials Engineering Degree (Faculty of Engineering - University of Porto, Portugal) 2001
Research Focus
Neovascularization driven by therapeutic agents represents a powerful strategy to treat ischemic diseases and is also critical to virtually all tissue-engineering approaches. Specifically, spatiotemporal control over the delivery of angiogenic agents may be crucial to guide the formation of new vascular networks. The hypothesis underlying my work is that the formation of neovasculature in an ischemic hindlimb can be governed by the regulated delivery of endothelial progenitor cells and growth factors from polymeric materials.Overall, I hope that my work could lead to a new generation of therapeutic strategies for treating ischemic vascular diseases, and might also have a great impact on current efforts to engineer and regenerate a wide variety of tissues via cell transplantation.
Publications
- Chen RR, Silva EA, Yuen WW, Brock AA, Fischbach C, Lin AS, Guldberg RE, Mooney DJ. Integrated approach to designing growth factor delivery systems. FASEB J. 2007 Jul 20.
- Hao X, Silva EA, Mansson-Broberg A, Grinnemo KH, Siddiqui AJ, Dellgren G, Wardell E, Brodin LA, Mooney DJ, Sylven C. Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction. Cardiovasc Res. 2007 Jul 1;75(1):178-85.
- Mooney DJ, Silva EA. Tissue engineering: a glue for biomaterials. Nat Mater. 2007 May;6(5):327-8.
- Silva EA, Mooney DJ. Spatiotemporal control of vascular endothelial growth factor delivery from injectable hydrogels enhances angiogenesis. J Thromb Haemost. 2007 Mar;5(3):590-8.
- Chen RR, Silva EA, Yuen WW, Mooney DJ. Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Pharm Res. 2007 Feb;24(2):258-64.
- Silva EA, Mooney DJ. Synthetic extracellular matrices for tissue engineering and regeneration. Curr Top Dev Biol. 2004;64:181-205.