Photoacoustic imaging combines the high temporal and spatial resolution of ultrasound with the good contrast and spectral nature of optics. This techniques is “light in/sound out” as opposed to traditional “sound in/sound out” ultrasound. In this lecture, I will present four case studies that highlight the power of photoacoustic imaging to address the needs of the medical community. In the first, I will detail an activatable nanoparticle to image reactive oxygen species. Next, I will describe uranium-sensitive nanoparticles as a sensing agent for defense threats. Third, I discuss a mouthpiece for acoustic dental imaging that non-invasively collects pocket depth measurements. Finally, I will detail photoacoustic imaging with a wearable transducer for therapeutic drug monitoring of heparin.
Jesse V. Jokerst is an Assistant Professor in the Department of NanoEngineering at UC San Diego. Dr. Jokerst graduated cum laude from Truman State University (Kirksville, Missouri) in 2003 with a B.S. in Chemistry and completed a Ph.D. in Chemistry at The University of Texas at Austin in 2009 with John T. McDevitt. Jesse was a postdoc with Sam Gambhir at Stanford Radiology from 2009-2013 and was an Instructor in that same department from 2013-2015. At Stanford, Jesse received a prestigious American Cancer Society Postdoctoral Fellowship, a Burroughs Wellcome Collaborative Research Training Grant, and an NIH R25 Postdoctoral Fellowship. Jesse started at UCSD in July of 2015, and his research focuses on novel probes as acoustic contrast agents. He is currently funded under the NIH’s K99/R00 Pathway to Independence and DP2 New Innovator Awards.