Abstract: D. E. Shaw Research (DESRES) is a New York–based independent research laboratory that conducts scientific research in the field of computational biochemistry. Their group is currently focusing primarily on long molecular dynamics (MD) simulations involving proteins and other biological macromolecules of potential interest from both a scientific and a pharmaceutical perspective. An integral part of their effort consists of designing and developing custom hardware and software to carry out this research. They are also pursuing drug discovery programs, leveraging the insights enabled by their novel technologies, with an initial focus on drug targets that have proved resistant to traditional drug discovery methods. Their team includes computational chemists and biologists, computer scientists and applied mathematicians, and computer architects and engineers, all working collaboratively within a tightly coupled interdisciplinary research environment under the leadership of their chief scientist David Shaw. Join them for an overview of their work and a discussion of current openings in the lab.
Tamas Szalay develops software and algorithms for Anton. He holds a B.S. in physics and computer science from California Institute of Technology and a Ph.D. in applied physics from Harvard University. At Harvard, Tamas focused on developing a nanopore DNA sequencing apparatus by investigating physical aspects of pores and designing new algorithms for nanopore sequence error correction. Tamas has also conducted research at the Max Planck Institute for Astrophysics in Garching, Germany.
Yakov Pechersky is involved with simulation studies of biological systems. He holds an A.B. in chemical and physical biology with a minor in Jewish studies from Harvard University. As an undergraduate in Professor Emily Balskus’s lab, Yakov characterized enzymes in the biosynthetic gene cluster for cremeomycin and developed an algorithm to discover and predict bioactivity of cryptic natural products in bacterial genomes. Prior to joining DESRES, Yakov worked as an Organism Engineer and Designer at Ginkgo Bioworks in Boston, where, among other projects, he engineered yeast and bacteria to produce flavors, fragrances, and nutraceuticals, and developed a new protein alignment algorithm.