Nanomedicine for Acute Critical Illness

28 Feb
Topics in Bioengineering
Jake Brenner, UPenn
Thursday, February 28, 2019 - 4:30pm to 5:30pm
60 Oxford Street, Room 330

As a physician in the intensive care unit (ICU), I take care of patients afflicted with acute, severe illnesses, such as life-threatening lung inflammation, heart attacks, strokes, and many more.  These diseases have a number of commonalities that make them attractive targets for nanomedicine: they currently have poor treatment options; the patients have multi-system organ dysfunction and thus do not tolerate off-target drug side effects; and they already have intravascular catheters in place.  Therefore, my lab develops diagnostic and therapeutic nanocarriers targeted to organs affected by various acute critical illnesses.  We achieve such targeting with combinations of affinity moieties, hitchhiking on endogenous cells, and by combining nano-scale targeting with macro-scale medical devices.

Jennifer Vasquez