Microfluidics and lab-on-a-chip carry the promise of rapid analysis, economy of reagents and use at the point-of-care analysis using minute amounts of reagents. Here, our efforts in making microchannel-based capillary microfluidics will be discussed, and the realization of advanced circuits – termed capillaric circuits in analogy to electronic circuits –that realize complex fluidic operation simply by a combination of the microscale geometry and control over surface chemistry. Basic elements including capillary pumps, trigger valves, retention flow valves, air valves and so on, will be introduced, and their use for sequential autonomous and pre-programmed delivery of 96 reagents as well as for timing illustrated. The application of capillaric circuits for a rapid diagnostic for urinary tract infection in 7 min, measles vaccination testing, and automation of the thrombogram to characterize haemostatic-thrombotic mechanism of the blood will be presented. The transition from microfabrication to rapid prototyping and 3D printing of capillaric circuits makes them easy-to-fabricate and readily accessible to a wide audience.
David Juncker conducted his PhD research at the IBM Zurich Research Laboratory from 1999–2002. He then pursued his studies as a postdoctoral fellow first at IBM Zurich until 2004, and then one year at the Swiss Federal Institute of Technology in Zurich. David joined McGill University in 2005 as an Assistant Professor in the Biomedical Engineering Department. He was promoted to Associate Professor with tenure in 2011 and became a Full Professor in 2016. He currently serves as Chair of the department. He received a number of awards, including a Canada Research Chair and a Fellowship for his sabbatical at the DKFZ in Germany.
David's current interests are in various areas of micro and nanobioengineering An emerging theme is liquid biopsies, and the analysis of proteins, exosomes and circulating tumor cells in plasma, and to this end his lab works on scalable protein analysis technologies, digital omics of single exosome, and isolation of circulating tumor cell clusters; Additional interests include microfluidic capillaric circuits for point-of-care diagnostics, duplexed aptamers, nucleic acid detection in single cells, as well as 3D bioprinting and miniaturized organs-on-a-chip.